BioChem Final Exam

BioChem Final Exam - BioChem Final Exam 1) A) Why does...

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BioChem Final Exam 1) A) Why does adipose tissue lacks glycerol kinase but still can produce Glycerol 3-P? Adipose tissue lacks glycerol kinase because adipocytes cannot phosphorylate glycerol, G3P is formed during Glyceroneogenesis (pyruvate -> DHAP-> G3P via cytosolic NAD-linked G3P dehydrogenase) B) Two different ways of producing NADPH in a Cell? 1) Glucose 6-phosphate irreversibly converted to ribulose 5-phosphate in pentose phosphate pathway 2) 2 NADPH are produced for each molecule of glucose that enters the hexose monophosphate pathway C) Two examples of eicosanoids. Prostaglandins, thromboxanes, and leukotrienes D) The site of inhibition of electron transport by either cyanide or CO. Complex IV E) Why 2, 4 –dinitrophenol is an oxidative phosphorylation uncoupler. It is a weak acid with hydrophobic properties that diffuse across the mitochondrial membrane releasing a proton, thus dissipating the proton gradient. F) The immediate common precursor for triacyglycerol and glycerophospholipid. Phosphatidic acid (diacylglycerol-3-phosphate) G) The mode of action of aspirin. Irreversibly inactivates the cyclooxygenase activity of COX by acetylating a ser residue and blocking the enzyme active site, inhibiting synthesis of prostaglandins and thromboxanes. H) Isoprene unit and a vitamin that contains the isoprene unit.
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This note was uploaded on 01/26/2009 for the course CHEMISTRY 216 taught by Professor Feng during the Spring '05 term at Temple.

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BioChem Final Exam - BioChem Final Exam 1) A) Why does...

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