Patho. Micro. Test IV IV

Patho. Micro. Test IV IV - Human Herpesviruses DNA...

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Human Herpesviruses DNA enveloped viruses Virion is about 150 nm in diameter DNA core is surrounded by an icosadeltahedral capsid Can cause lytic, persistent, latent/recurrent and immortalizing infections Virus is ubiquitous, and infections are common The virus is divided into three subfamilies based on differences on viral characteristics Herpes Simplex Virus (HSV) Two types, HSV-1 and HSV-2 Causes lytic infections in fibroblasts and epithelial cells, causes latent infections in neurons HSV-1 occurs above the waist, HSV-2 occurs below the waist Cytolysis is usually caused by the virus-induced disruption of the host cell physiology Intranuclear inclusion bodies are produced, and syncytia formation is initiated Causes infection through breaks in skin or mucosal membranes, then produces vesicular lesions, then causes neuron infection Recurrence can be activated by various stimuli such as sunlight, fever stress, but it is less severe and more localized than the primary infection Epidemiology HSV occurs only in humans Life-long infection, unusual to find adults that don’t have it in their blood if they had it at a younger age Recurrent disease Can spread to another person and that person may not have symptoms, asymptomatic shedding Close contact is required to spread While both types, HSV-1 and HSV-2, cause genital and oral lesions, HSV-1 mainly comes from oral contact with another mouth or oral contact with skin or fingers, and fomites, while HSV-2 comes from sexual contact, and can be spread to neonates from infected mothers during birth Clinical Syndromes Usually painful but benign Starts as a clear vesicle, then turns into a pustular lesion, then an ulcer, then it is a crusted lesion Cold sores and fever blisters are common in people, even though they have never had clinically apparent primary infection Herpes pharyngitis is common in adults with throat soars
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Herpes keratitis is an infection of one eye, may cause blindness and scarring Herpes whitlow is an infection of the finger, usually nurses attending HSV patients get this Genital Herpes Lesions occur on male penis, and the urethra Lesions occur on male vulva, vagina with a discharge, cervix, perianal, and inner thigh, itching occurs Painful The primary infection includes fever, sickness, and inguinal adenitis For a recurrent infection, shorter and less severe, usually experience prodrome of burning and tingling in the area in which the lesions eventually erupt People can shed asymptomatically at any time throughout their life Herpes gladiatorum is an infection of the body Eczema herpeticum is acquired by children with active eczema, and from there it may go to the skin Herpes encephalitis causes lesions on one temporal lobe, and is the most common cause of sporadic encephalitis Herpes meningitis comes from a complication of genital herpes, and symptoms resolve
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This note was uploaded on 04/15/2008 for the course MCB 3203 taught by Professor Safraneck during the Spring '08 term at University of Central Florida.

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Patho. Micro. Test IV IV - Human Herpesviruses DNA...

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