Introduction to Neurobiology - Lecture Notes 03 - Resting Potential

Introduction to Neurobiology - Lecture Notes 03 - Resting Potential

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BioNB222 Spring 2008 Cornell University Joseph Fetcho 1 Lecture 3. Resting Potential Lecture Outline 1. Goldman equation. The Nernst potential describes an equilibrium potential when only one ion is permeable. Things are more complicated in neurons because the membrane can be permeable to multiple ions and the permeabilities can change in response to inputs from other neurons and changes in membrane voltage. A . Intuitively, if the permeability to an ion goes up, then we might expect that the membrane potential of a cell will move toward the equilibrium potential of that ion. B. This idea that the membrane potential (V m ) at any time is governed by the equilibrium potentials of the individual ions along with their relative permeabilities is described quantitatively by the Goldman equation. V m (in millivolts)=58 log (P k [K] out + P Na [Na] out + P Cl [Cl] in )/ (P k [K] in + P Na [Na] in + P Cl [Cl] out ) This equation is commonly written with relative permeabilities, with the permeability of K + =1 and b and c representing the permeabilities of the other ions relative to it.
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