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thera-flow-sheet.docx - Name of the drug, dosage, and route...

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Name of thedrug,dosage,and routeMechanism of ActionIndication for the patientSpecial consideration andresponsibilitiesLosartanLosartan is a competitiveangiotensin II receptorantagonist. It selectivelyblocks AT1receptorsfound in many tissues(e.g. vascular smoothmuscle, adrenal gland),thereby reducing thevasoconstricting andaldosterone-secretingeffects of angiotensin II.For hypertension (oral)100 mg daily.Patients with history ofangioedema, volume-and/or Na-depletion, heartfailure, unstentedunilateral/bilateral renalartery stenosis, aortic ormitral stenosis, cirrhosis.Black race. Renalimpairment and mild tomoderate hepaticimpairment. Children andelderly. Lactation.AmlodipineAmlodipine, adihydropyridine Ca-channel blocker, reducesperipheral vascularresistance and BP byrelaxing coronaryvascular smooth muscleand coronaryvasodilation throughinhibition of Ca iontransmembrane influxinto cardiac and vascularsmooth muscles.For hypertension (oral)10 mg dailyPatients with aortic stenosis,congestive heart failure,hypertrophiccardiomyopathy, outflowtract obstruction, severeobstructive coronarydisease. Hepaticimpairment. Elderly andchildren. Pregnancy andlactationAtorvastatinAtorvastatin selectivelyand competitivelyinhibits HMG-CoAreductase, the enzymethat catalyses theconversion of HMG-CoAto produce mevalonate.The reduction ofmevalonate productionresults to acompensatory increasein the expression of LDLreceptors andstimulation of LDLOralFor heterozygous familialhypercholesterolaemia orfor patients who require>45% reduction in LDL-cholesterol:40 mg ODPatients with diabetesmellitus, hypothyroidism,hereditary musculardisorders, recent stroke,transient ischaemic attack,severe acute infection,hypotension, major surgery,predisposing factors forrhabdomyolysis, severemetabolic disorder anduncontrolled seizures. Notindicated for elevatedchylomicrons as the primarylipid abnormality. Patients

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Term
Fall
Professor
N/A
Tags
stenosis, Tazobactam

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