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Unformatted text preview: Lecture 6 EEB 13 24 January 2008 Dr. Hespenheide [genetic material is DNA, base pairs of DNA molecules code for proteins] proteins - mostly enzymes, facilitate chemical reactions macromolecules, chains (polymers) of amino acids AA 1 AA 2 AA 3 AA 4 AA 5 AA 6 .... AA n- length of proteins - 10s 100s of AAs amino acids - structure H H H HN- C - COOH vs. H - C - COOH R H [amine] [acid] [acetic acid - vinegar]- amino acids combined by condensation - H removed from the amine group and an OH from the acid group to make the H 2 O, water- kinds -20 different amino acids in proteins of living organisms - different Rs- [many other kinds of amino acids known than those in proteins] genetic code DNA protein sequence of sequence of base pairs amino acids [DNA] BP - BP - BP - BP - BP - BP - etc ....... A - T - C- G - A - T- etc ....... [protein] AA 1 AA 2 AA 3 etc .- thus a triplet code - 3 base pairs 1 amino acid (DNA) (protein)- sequencing the human genome = determining the sequence of the base pairs of DNA of all 23 different chromosomes- every individual has slightly different DNA, so we can identify relationships among individuals, identify criminals, et . structure of proteins determines activity as enzymes - 4 levels of structure primary structure - sequence of AAs, not functional by itself- sequencing proteins = determining primary structure [secondary structure - not important] tertiary structure - pattern of folding of molecule- folding forms active sites - places where reacting compounds bind- unfolded protein said to be denatured, not functional; e.g. , heating (cooking) denatures proteins (of food) quaternary structure - several polypeptides form protein- example: hemoglobin - carries O 2 in blood...
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This note was uploaded on 04/16/2008 for the course EE BIOL 13 taught by Professor Hespenheide during the Winter '08 term at UCLA.
- Winter '08