Exam 3-v1-Key - Biology 760 Exam#3 Version 1 NAME Multiple...

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Biology 760 Exam #3, Version 1 April 24, 2014 NAME: Multiple Choice Questions (2 points each) : Choose the one alternative that best completes the statement or answers the question. 1. Which of the following is not a characteristic of aging cells? a. Lengthening of telomeric DNA sequence b. Increased telomere erosin c. Repression of telomerase enzyme d. Limited proliferation capacity e. Both b and d are correct 2. Which of the following cell types is directly affected by drugs that inhibit the function of human Telomerase Reverse Transcriptase (hTERT) 3. Which of the following represents the sequence of nucleotides carried by the hTERT enzyme complex? 4. Which of the following conditions can confer immortalization to a cell? 5. Which of the following is correct about hTERT? a. hTERT has reverse transcriptase activity. b. hTERT is de-repressed in normal cells. c. hTERT has DNA polymerase activity. d. hTERT carries a DNA template complementary to the 3’ overhand of telomeric end. e. Both a and d are correct
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6. Which of the following is required for acquisition of immortalization by human cells? 7. Which of the following mechanisms would not directly contribute to cancer cell transformation? 8. Activity of which of the following enzymes is responsible for erosion of telomeres? 9. Consider a transgenic mouse carrying an active Ras oncogene in epithelial cells of skin. Which of the following conditions would induce skin carcinomas in these transgenic mice at high frequency? a. Repeated exposure to a tumor initiating agent b. Repeated exposure to a tumor promoting agent c. Inactivating mutations in p53 gene d. Both a and c are correct e. All of the above
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