ExpModelSkinCarcinomaMice - ExperimentalModelof...

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Experimental Model of Skin Carcinoma in Mice Jonathan Lee
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Background In the 1940s, it was known that mutagenic agents induce cancer, and researchers wanted to show that non-mutagenic agents could also induce cancer Developed a mouse model to induce skin cancers using both mutagenic and non-mutagenic agents
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Keywords Tumor Initiator - mutagen that can cause cancer Tumor Promoter - non-mutagen/irritant that drives cell proliferation and can cause cancer DMBA - 7,12-Dimethylbenz(a)anthracene Tar constituent TPA - 12-O-Tetradecanoylphorbol-13-acetate Irritant prepared from the seeds of a croton plant
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Case #1 Daily painting of DMBA 3 Months Later Carcinoma Case #2 Daily painting of TPA 3 Months Later No Tumor Case #3 Single painting of DMBA 3 Months Later No Tumor
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Case #5 Single painting of DMBA /Daily Painting of TPA 3 Months Later Papilloma The initial DMBA application is ‘initiating’ something so the following TPA
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