Handout Lecture 17

Handout Lecture 17 - Handout Lecture 17 Irreversibility...

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Handout Lecture 17 Irreversibility problems Use two different sets of enzymes Four reactions in gluconeogenesis that bypass the three irreversible reactions in glycolysis. (You should know all the substrates, products, cofactors, and enzyme names for the 4 reactions) (you can find cofactors on p. 544) PEP -> Pyruvate F-1,6-BP -> Fructose 6 Phosphate Glucose 6 phosphate -> Glucose Coordination of glycolysis and gluconeogenesis
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Cori Cycle The formation of lactate buys time and shifts part of the metabolic burden from muscle to other organs Glucose-6-phosphotase Catalyzes fructose-6-phosphate -> glucose Glucose-6-phosphatase in the liver is important for maintaining glucose level Muscle does not have glucose 6 phosphatase o Muscle only breaks down glucose, never forms it Futile Cycles A fultile cycle is the circular formation and breakdown of a product resulting in the continuous hydrolysis of ATP the futile cycle enzymes in glycolysis and gluconeogenesis are:
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This note was uploaded on 04/16/2008 for the course PSYC 108 taught by Professor Staff during the Spring '06 term at UC Irvine.

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Handout Lecture 17 - Handout Lecture 17 Irreversibility...

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