handout#5 - MOHAMMAD H. MAKTABI Email: mmaktabi@ucsd.edu...

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MOHAMMAD H. MAKTABI Email : mmaktabi@ucsd.edu SXN : Mondays 5-5:50PM 6-6:50PM Handout # 5 I. GLUCONEOGENESIS ± anabolism - assembly of small things to form big things. Breaking down and building up. ± Gluconeogensis - the formation of glucose from non-hexose precursors. (Eg. Lactate ( The Cori Cycle ), pyruvate, glycerol, and certain amino acids). This is opposite of glycolysis. It uses a lot of energy. 3 different bypasses : 1) pyruvate Î PEP 2) fructose 1,6 bisphosphate Î fructose 6- phosphate 3) glucose 6-phosphate Î glucose ± Glu-6-phosphatase in the liver is important for maintaining glucose levels. This enzyme is not found in the muscles. ± F2,6 BP is a regulator of this step. When glucose is abundant, so is F2,6 BP, which we know activates PFK-1 activity. It is used to control the glycolytic pathway. ± Bicarbonate binds with pyruvate to form OAA. ATP is drives this rxn. ± GTP is needed to drive the 2 nd rxn. A loss of CO
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This note was uploaded on 04/16/2008 for the course PSYC 108 taught by Professor Staff during the Spring '06 term at UC Irvine.

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handout#5 - MOHAMMAD H. MAKTABI Email: mmaktabi@ucsd.edu...

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