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BIO 225 - Abstract 3.docx - Carissa Poindexter 1 October...

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Carissa Poindexter1 October 2021BIO 225Dr. Kathryn PhillipsTitle: Activating newborn neurons suppresses depression and anxiety-like behaviorsAbstractObjectivesMajor depressive disorder (MDD) is a disorder hypothesized to be associated with issues in theneurogenesis in hippocampal dentate gyrus (DG).A common treatment of MDD isantidepressant medication which can increase neurogenesis, but these medications are notnecessarily targeted to excite the new neurons in a way to alleviate depression symptoms.Theobjective of this paper is to analyze results in testing of lab mice to see if targeting the neuronscreated and excited by antidepressants can make them more effective.MethodsThis study used 8- to 10-week-old, comparable mice assigned to a control group and anexperimental group that was dosed with fluoxetine, a known antidepressant.Another set of micewere bred to control expression of hM4Di and hM3D1 and given CNO to activate, and a groupof control mice were also used.

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Term
Spring
Professor
N/A
Tags
Selective serotonin reuptake inhibitor, Major depressive disorder, Antidepressant, Neurogenesis, Fluoxetine

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