BrookerChp7_NonMendelian

BrookerChp7_NonMendelian - Erasing then re-establishing...

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Chapter 7 – Non-Mendelian Inheritance I. Maternal effect A. Boycott and reciprocal cross in Limnea [Fig. 7.1] 1. Sturtevant’s proposal 2. More to oogenesis than ‘just’ meiosis [Fig. 7.2] B. Genotype of mother dictates offspring’s phenotype for maternal effect genes II. Epigenetic inheritance A. Dosage compensation – variable mechanism in different species [Table 7.1] 1. Differential expression and/or chromosome inactivation 2. X chromosome inactivation in female mammals [Figs. 7.3, 7.4] 3. Barr body and Lyon hypothesis [Experiment 7A; Figs. 7.4, 7.5, 7.6] 4. Molecular mechanism of X-chromosome inactivation [Figs. 7.7, 7.8] B. Genomic imprinting and monoallelic expression [Figs. 7.9, 7.10] 1. Overview of process Establishing imprint during gamete formation Maintaining imprint during embryogenesis, in somatic cells
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Unformatted text preview: Erasing, then re-establishing imprint during next round of gametogenesis 2. Role of DNA methylation in imprinting [Fig. 7.11] III. Extranuclear / cytoplasmic inheritance A. Chromosomal content of mitochondria, chloroplasts [Figs. 7.14, 7.15] 1. Endosymbiosis theory [Fig. 7.20] 2. Symbiotic infective particles B. Maternal inheritance [Table 7.4] 1. Heteroplasmy illustrated in four-o’clock plants [Figs. 7.16, 7.17] 2. Petite trait in yeast, Saccharomyces [Fig. 7.18] 3. Chloroplast/mitochondria inheritance in alga, Chlamydomonas [Fig. 7.19] IV. Study Suggestions A. Solved problems: S1, S2, S4 B. Conceptual questions: C1 - C4, C10, C11, C13 – C16, C18 – C20, C24 – C30, C35 C. Experimental questions: E4, E5, E8, E11...
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This note was uploaded on 04/16/2008 for the course BIO 325 taught by Professor Saxena during the Spring '08 term at University of Texas.

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