BrookerChp9_DNA_RNAStructure

BrookerChp9_DNA_RNAStructure - Chapter 9 Molecular...

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Chapter 9 – Molecular Structure of DNA and RNA I. Identifying DNA as genetic material A. Criteria for inherited material 1. Information 2. Transmission 3. Replication 4. Variation B. Frederick Griffith, Streptococcus pneumoniae , and transformation [Figs. 9.1, 9.2] 1. Type II vs. Type III S strains 2. Type IIR strain C. Avery, MacLeod, and McCarty [Fig. 9.3] D. Hershey and Chase, bacteriophage T2 [Figs. 9.4, 9.5] 1. Use of radioisotopes 2. Experiment [Fig. 9.6] II. Nucleic acid structure A. Nucleotide components [Figs. 9.8, 9.9] 1. Ribose and deoxyribose 2. Purines and pyrimidines 3. Phosphate group - nucleoside vs. nucleotide [Fig. 9.10] B. Single-strand nucleotide [Fig. 9.11] 1. Sugar – phosphate backbone and phosphodiester (covalent) bond 2. Asymmetric molecule: 5’ phosphate group, 3’ hydroxyl group C. Experiments underlying double-helix model 1. Linus Pauling developed α -helix protein model [Fig. 9.12] 2. Rosalind Franklin, Maurice Wilkins applied X-ray diffraction to highly purified
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BrookerChp9_DNA_RNAStructure - Chapter 9 Molecular...

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