BrookerChp11_DNAReplication

BrookerChp11_DNAReplication - Chapter 11 DNA Replication I...

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Chapter 11 – DNA Replication I. Replication models [Fig. 11.2] A. Watson & Crick: semiconservative [Fig. 11.1] B. Other possibilities: conservative model; dispersive model C. Meselson & Stahl experiment: Which model was correct? [Fig. 11.3] II. Bacterial DNA replication - basis of molecular studies [Table 11.1] A. Initiating replication 1. oriC and DnaA box sequences [Figs. 11.4, 11.5, 11.6] 2. DnaA proteins, DnaB helicases, and other DNA binding proteins 3. Double-strand separation: 5’ -> 3’ allowing bidirectional replication [Fig. 11.6] 4. DNA gyrase must ‘relieve’ supercoiling ahead of the replication forks [Fig. 11.7] 5. DNA primase must provide short RNA primer B. DNA polymerases: pol I * , pol II, pol III * , pol IV, pol V ( * understand molecular action) 1. Features of enzymatic capabilites: DNA pol I vs. pol III [Figs. 11.8 - 11.10 2. DNA pol III = complex, multicomponent enzyme [Table 11.2] C. DNA replication: Leading strand events and lagging strand events [Figs. 11.7, 11.13] 1. Helicase + primase = primosome; primosome + 2(DNA polymerase) = replisome 2.
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