BrookerChp13_Translation

BrookerChp13_Translation - Chapter 13 Translation of mRNA I...

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Chapter 13 – Translation of mRNA I. Recognition of connection between genetic inheritance and proteins A. Garrod and alkaptonuria [Fig. 13.1] B. Beadle and Tatum, Neurospora 1. Establishing a metabolic pathway [Table 13.1] 2. One gene – one enzyme hypothesis (modified one gene – one protein) II. Relationship between structural gene encoded in DNA, mRNA, polypeptide [Fig. 13.2] A. ‘Universal’ genetic code [Table 13.2] 1. Start codon 2. Stop codons 3. Degeneracy due to “wobble” B. Deciphering codon code 1. Use of synthetic RNA [Experiment 13A; Fig. 13.3] 2. Use of RNA copolymers [Table 13.5] III. Polypeptides: structure = function A. Amino acid building blocks [Fig. 13.5] 1. Nonpolar, aliphatic 2. Nonpolar, aromatic 3. Polar, neutral 4. Polar, acidic 5. Polar, basic B. Structure 1. Primary [Fig. 13.4] 2. Secondary [Fig. 13.6] 3. Tertiary [Fig. 13.6] 4. Quaternary [Fig. 13.6] C. Relationships between genes, protein, traits [Fig. 13.7] IV. Cellular components needed for translation
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BrookerChp13_Translation - Chapter 13 Translation of mRNA I...

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