BrookerChp23_DevelopmentalGenetics

BrookerChp23_DevelopmentalGenetics - Chapter 23...

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Chapter 23 – Developmental Genetics (Invertebrate) I. Basic concepts of development in multicellular organisms A. Body pattern formation from fertilized egg to adult requires 1. Cell division (mitosis) 2. Cell movement (migration) 3. Cell differentiation (specialization to specific function) 4. Cell death (apoptosis) B. Generation of body pattern depends on positional information mediated by morphogens , facilitating communication between cells within developing organism [Fig. 23.4] 1. Asymmetric morphogen distribution pre-established in ooctye 2. Asymmetric synthesis and release of morphogen (induction) 3. Cell-to-cell contact (cell adhesion) II. Overview of Drosophila development [Fig. 23.1] A. Embryogenesis 1. Oocyte (Note: anterior-posterior axis & dorsal-ventral axis) 2. Syncytial blastoderm w/ differentiated pole cells 3. Cellular blastoderm 4. Gastrula 5. Embryo (Note: segments roughly correspond to adult body segments) B. Larvae > pupae > adult C.
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BrookerChp23_DevelopmentalGenetics - Chapter 23...

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