(1-14) Lect.6.Transporters & Membrane Potential

(1-14) Lect.6.Transporters & Membrane Potential - How...

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1 How do cells take up ions and nutrients across membrane barriers ? Transporter proteins M. T. Fuller ECB3: Ch11 p372-375; Ch12 p387-403; Ch 20 p700-707 ECB3 Figure 11-1 Cells are enclosed by a plasma membrane •Barrier •Organizational Surface •Battery •Transport A membrane provides: A membrane requires: 11_04_membrane.view.jpg The plasma membrane is a lipid bilayer with embedded proteins ECB3 Figure 11-4 (~50 atoms) Barrier Battery Organizational Surface
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2 12_02_diffusion_rate.jpg The hydrophobic core of the lipid bilayer presents a barrier to charged ions and many nutrients lipid bilayer ECB3 Figure 12-2 Rate depends on size How do cells move ions, nucleotides, nutrients across membranes? 12_05_carrier_proteins.jpg Cells use proteins to transport nutrients and ions across their various membranes We have already seen that pyruvate produced by glycolysis in the cytoplasm is transported into the mitochondrial matrix to be further oxidized to acetyl CoA Q?: What other transport events have you already learned about? Transport proteins are usually very selective H + Figure Q14-21a Essential Cell Biology (© Garland Science 2010) We have already seen how H+ ions are transported across the mitochondrial inner membrane
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3 Figure 14-23 Essential Cell Biology (© Garland Science 2010) Energy driven conformational change coupled with change in affinity for H+ drive transport of the ion
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