Biology 225- FinalExamQuestions

Biology 225- FinalExamQuestions - BIOL 225 Comprehensive...

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BIOL 225: Comprehensive Questions for Final Exam Your final exam will contain 50 points of comprehensive questions asking you to integrate material covered over the course of the semester. This study guide contains some questions that will appear on the exam, although it is not a complete prediction of the exam. (In other words, you will not be asked to answer all of these questions, and there may be material on the exam that is not on this study guide.) NOTES: 1) You are to generate answers to the questions on your own. • You may not work with your classmates or other 225 students to answer the questions. • You may not ask 225 TAs or tutors for any help answering the questions. They have been instructed not to help you. • You may not ask your instructor or any other 225 instructor for assistance in answering the questions. 2) These questions are comprehensive , which means that your answers should be the same. Details, details, details—but make sure they are the pertinent details! Now is the time to demonstrate that you can apply your vast knowledge base to answering a question accurately and completely, yet succinctly. Question #1: This question will be on your exam . You will be expected to reconstruct your answer for the exam—that is, you will not be able to merely turn in a response written in preparation for the exam nor will you be able to use notes. 1) Cystic fibrosis results from a non-functioning CFTR (cystic fibrosis transmembrane conductance receptor). Loss of function of the receptor results in altered transport of salt and water across the epithelial layer of the lung alveoli due to an inability of CFTR to transport chloride ions (Cl - ) correctly. This loss of transport function has effects on many organ systems, leading to a variety of symptoms associated with CF. • One of the most common genetic mutations responsible for a defective CFTR is a 3 base pair deletion which results in an in-frame deletion of a single phenylalanine amino acid from the CFTR protein. Apply your knowledge of the
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