PYRUVATE DEHYDROGENASE

PYRUVATE DEHYDROGENASE - Ok Guys, so I was going to type it...

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Ok Guys, so I was going to type it out, but instead I found it on a site, so this is an explanation of it… HONESTLY… just know AT LEAST this much Pyruvate dehydrogenase catalyzes the conversion of pyruvate to acetyl-Coenzyme A (acetyl-CoA). The reaction is coupled to the reduction of NAD + to NADH. The reaction is an example of an oxidative decarboxylation since the other product is carbon dioxide (CO 2 ). Acetyl-CoA is subsequently used up in the citric acid cycle and in fatty acid synthesis. THE REST HERE IS GOOD TO KNOW IF YOU HAVE TIME, BUT I WOULD FOCUS ON OTHER THINGS: This is a very complicated reaction. It turns out that the enzyme pyruvate dehydrogenase is actually a complex of several different activities. From now on I'll refer to it as the pyruvate dehydrogenase complex (PDC). The first step in the reaction is the decarboxylation step and it requires a special cofactor called thiamine pyrophosphate (TPP). This is vitamin B 1 and it explains why that vitamin is essential. Carbon dioxide is released in this step and the remaining 2-carbon fragment
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PYRUVATE DEHYDROGENASE - Ok Guys, so I was going to type it...

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