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Unformatted text preview: BIBC 102 Scheffler/WI2008 TA: Jacqueline Vu (email@example.com) Worksheet 2 OH: Wednesdays @12:10-1:10pm in YORK 3010B Feedback Inhibition : end product of the pathway inhibits enzyme early in the pathway- the product at the end of a pathway inhibits and ultimately slows the entire pathway- Purpose: The precursor is saved to be used for other reactions and is not wasted- Ex: LNC 6-28: L-Thr is converted to L-Ile and the enzyme of the first reaction in the pathway is inhibited by the end product, L-Ile. Allosteric Enzymes - These do NOT act as normal M&M enzymes. - The substrate binding site is on the catalytic substrate , and the modulator/effector binding site is on the regulatory subunit- The binding of the modulator to its site will cause a conformational change of the catalytic subunit . o This either helps the substrate bind to the active site with an even higher affinity in the case of using positive modulators o Or prevents the substrate from binding to the enzyme active site in the case of using negative modulators . - The enzyme will return to its normal state once the modulators dissociate from its site. o Curve with homotropic enzymes (+ modulators) Homotropic enzyme: binding site acts as a both active site and regulatory site to increase substrate affinity....
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This note was uploaded on 04/15/2008 for the course BIBC 102 taught by Professor Price during the Winter '02 term at UCSD.
- Winter '02