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JV9 Key - BIBC 102 Metabolic Biochem Jacqueline Vu...

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BIBC 102- Metabolic Biochem Jacqueline Vu 3/12/08 Worksheet #9            http://groups.google.com/group/     bibc102jackie     Please Fill out Evaluations    http://biology.ucsd.edu/genericsurvey/studenttaeval.jsp                                                                                                             ♫ ♫ ♫ ♫ ♥ ♥ ♫ ♫ ♫ ♫ ♪ ♪ ♥ ♥ ♥ ♥ ♫             ♫ ♫ FA Synthesis     1. Where does FA synthesis take place?  2. A starting material for FA synthesis is  Acetyl-CoA .  It will then be converted to  malonyl-CoA  by enzyme  acetyl-Coa carboxylase .  This enzyme is a single  polypeptide with 3 different activities:  biotin carrier protein, biotin carboxylase and  transcarboxylase .  At the  biotin carboxylase  region, ATP is involved to the  attachment of HCO 3 -  to a nitrogen in the biotin ring. At the  transcarboxylase  region , the activated CO 2  is transferred from biotin to  acetyl-CoA , producing  malonyl-CoA . General Equation: 3. Both acetyl-CoA and malonyl-CoA are substrates for the fatty acid synthase.  Describe with structural formula the steps required to make the first 4C molecules  in the process of FA synthesis 1
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BIBC 102- Metabolic Biochem Jacqueline Vu 3/12/08 Worksheet #9            http://groups.google.com/group/     bibc102jackie     Please Fill out Evaluations    http://biology.ucsd.edu/genericsurvey/studenttaeval.jsp                                                                                                             ♫ ♫ ♫ ♫ ♥ ♥ ♫ ♫ ♫ ♫ ♪ ♪ ♥ ♥ ♥ ♥ ♫             ♫ ♫ In general, it is a 4-step sequence to add 2C to a growing fatty acyl chain: a. Condenstaion  of an activated acyl group and 2C derived from malonyl- CoA with elimination of CO from malonyl group, extends acyl chain by 2C b. Reduction : beta-keto group is reduced to an alcohol c. Dehydration  of H 2 0 creates a double bond d. Reduction : double bond is reduced to form the corresponding saturated  fatty acyl group. 4. Radioactive  14  CO 2  was used in the production of malonyl-CoA in a bacterial extract.  Could this radioactive starting material now be used to make radioactive fatty acids  by an animal FA synthase? Explain briefly.  No, CO leaves after the first condensation reaction of FA synthesis.
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