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Unformatted text preview: Lecture 9 Alcohol 1.) Absorption 2.) Metabolism 3.) Health risk Mon 2/11 4-5 WLH 2005 TA review session: Sub Feb. 10: 2-5 WLH2001 9 Q 1 for each lecture Short answers Alcohol (ethanol)- Accounts ~5% of total energy intake in the US- Content: 7kcal/gm Binge drinking 4+ drinks for women, 5+ drinks for men, in a row -> lead to alcohol toxicity and death Ethanol metabolicm AOH pathway- Occurs in cytosol: yields energy Ethanol Alcohol dehydrogenase (Zn) CH 3-CH 2-CH (NAD + - NADH) acetylaldehyde | ( NAD + - NADH) alcohol dehydrognase | (ALDH drugs for alcoholics inhibit ACOH) Acetic Acid CH 3 COCH CoA | Synthase Acetyl CoA CH 3 COSCOH | | ATP <- TCA Cycle FAT 70-90% of ethanol metabolized in liver , 10-30% in stomach @ rate of 5-7 g/hr ~ can of 12 oz beer Aldehyde dehydrogenase (ALDH) Alcohol dehydrogenase (ADH) ALDH comes in 2 isoforms ALDH 1 high km in cytosol ALDH 2 Low km in cytosol The lower the km, the higher the ability of alcohol to bind- East azn mutation in aldh2 maprotyol...
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- Winter '08