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Unformatted text preview: HbS/HbA=mild anemia (BUT malaria resistant) HbA/HbA=normal (die of malaria) HbS-sickle cell allele HbA-normal allele No advantage where there is no malaria!! Hardy-Weinberg Equilibrium Null/theoretical model Tests if allele frequencies change from one generation to the next Populations NOT undergoing microevolution are in H-W equilibrium H-W Assumptions Infinitely large population No mutation No migration Random mating No natural selection p= dominant allele frequency (A) q=recessive allele frequency (a) ALLELE frequencies: p + q = 1 or f (both alleles) = 1 GENOTYPIC frequencies: p 2 +2pq+q 2 =1 p 2 =% of popln that is homozygous dominant (AA) 2pq=% of popln that is heterozygous q 2 =% of popln that is homozygous recessive (aa) HW Equilibrium When a population is NOT in HWE (BTWall populations are NOT in HWE), then p and q are changing p goes upthen q goes down (or vice versa) and this is microevolution (change in gene frequencies)...
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