5_EvolMech1

5_EvolMech1 - Evolutionary Mechanisms I 22.1-22.2...

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Evolutionary Mechanisms I 22.1-22.2
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2 Populations evolve, individuals do not Simpson video
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3 The Modern Synthesis Established in the 1930s and 1940s Connected the units of evolution (genes) with the mechanism of evolution (selection on populations) Integrated Darwinian evolution with Mendelian genetics +
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4 Architects of the modern synthesis JBS Haldane G Ledyard Stebbins Theodosius Dobzhansky Sewall Wright
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5 Hardy Weinberg principle Given a series of assumptions, allele frequencies and genotype frequencies will not change between generations The assumptions are: No selection No mutation No migration Infinitely large population Random mating
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6 AA Aa aa AA Aa aa aa Generation 1, “Gene pool” Generation 2, allele freq p and q allele freq p and q AA Aa aa AA Aa aa aa A a a A A a a A a If these assumptions are met, allele and genotype frequencies will not change between generations
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7 Some terminology Imagine a populations made up of 100 diploid individuals: 40AA, 40Aa and 20aa The genotype frequencies are?………. The allele frequencies are?……. The genotype numbers are?……. The allele numbers are…. .
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8 Remember the multiplication and addition rules? If you just roll one die, what’s the chance of getting a 4? What’s the chance of getting 4 twice in a row? The combined probability of independent events occurring together is the product of their individual probabilities
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9 If you just roll one die, what’s the probability of getting either a 4 or a 6? The combined probability of 2 mutually exclusive events is the sum of their individual probabilities
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10 A A a a 0.5 0.5 Eggs Sperm Under Hardy-Weinberg equilibrium, allele frequencies predict genotype frequencies Here’s a numerical example using Punnett squares: 0.5 0.5 0.25 AA 0.50 Aa 0.25 aa Freq A = p = 0.5 Freq a = q = 0.5 .25 AA .25 aA .25 Aa .25 aa
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11 A A a a p q Eggs Sperm Here’s the same thing using symbols. .. p q p 2 AA 2pq Aa q 2 aa Always check your work: p + q = 1 p 2 + 2pq + q 2 = 1 p 2 AA pq aA pq Aa q 2 aa
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12 The same principle applies when there are more than 2 alleles (although we’ll need to use more than p and q) Alleles: A 1 A 2 A 3 A 4 A 5 A 6 ... Allele frequencies:
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This note was uploaded on 02/19/2008 for the course BISC 120Lg taught by Professor 11:00-01:50pm during the Fall '06 term at USC.

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5_EvolMech1 - Evolutionary Mechanisms I 22.1-22.2...

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