chapter 16 - DNA as the basis of inheritance Watson J D,...

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1 DNA as the basis of inheritance Watson J.D. and Crick F.H.C. 1953 Genetical implications of the structure of Deoxyribonucleic Acid. Nature 171, 964-967. Watson J D, Crick F H (1953) Molecular structure of nucleic acids: a structure for deoxyribose nucleic acid. Nature 171: 737-738. Maurice Wilkins with X-ray crystalographic equipment about 1954 Photo 51 x-ray diffration of wet DNA showing the B form double helix taken by Rosalind Franklin Sugar–phosphate backbone 5 end Nitrogenous bases Thymine (T) Adenine (A) 3.4 nm 1 nm Cytosine (C) DNA nucleotide Phosphate 3 end Guanine (G) Sugar (deoxyribose) Key features of DNA structure 0.34 nm X-ray diffraction of DNA 5 end 3 end Hydrogen bond 3 end 5 end Adenine (A) Thymine (T) Sugar Sugar PURINES AT Guanine (G) Cytosine (C) Sugar Sugar PYRIMIDINES G C
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2 3.4 nm 1 nm Purine + purine: too wide Pyrimidine + pyrimidine: too narrow 0.34 nm Purine + pyrimidine: width consistent with X-ray data DNA replication as proposed by Crick & Watson 1954 Complementary strands of DNA Separation of DNA strands Parental strands act as a templates for replication Replication is completed Crick, F.H.C. & Watson, J.D. 1954. The complementary structure of Deoxyribonucleic Acid. Proc. Roy. Soc. (A) 223: 80. Conservative model Parental strands reassociate after replication Semi-conservative model Parental strands separate A Replication and join new strands after replication Dispersive model Parental strands fragment and mix
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This note was uploaded on 04/16/2008 for the course BIO 131 taught by Professor Paz y mino during the Fall '08 term at UMass Dartmouth.

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chapter 16 - DNA as the basis of inheritance Watson J D,...

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