2nd+MIDTERM+KEY+2007

2nd+MIDTERM+KEY+2007 - VM PMI 126 1. 2ND MIDTERM...

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2 ND MIDTERM EXAMINATION WINTER 2007 1. Which of the following contribute to the generation of B cell receptor diversity ? a. VD joining of the heavy chain genes b. VJ joining of the light chain genes c. Addition of P nucleotides during VJ joining of light chain genes d. All of the above e. a and b only 2. What is the final result of allelic exclusion in B lymphocyte development? a. A single B lymphocyte only expresses one class of antibody at a time b. A single B lymphocyte only expresses a B cell receptor with a single specificity c. A single B lymphocyte expresses one heavy chain gene and both κ and λ light chain genes d. All of the above e. None of the above 3. Which of the following enzymes play a direct role in “rearrangement” of variable and diversity genes within the B cell receptor? a. TdT (terminaldeoxynucleotidyl transferase) b. CLIP c. RAG-1 d. TNFα e. None of the above 4. Which of the following enzymes plays a direct role in adding nucleotides, in the absence of a template , to the sites of V-D heavy chain joining in the generation of B cell receptors? a. TdT b. CLIP c. Rag-1 d. TNFα e. None of the above 5. Antibody binds to antigen, with the affinity of the binding being determined by the number of covalent bonds formed between the antigen and the antibody binding site. a. True b. False 6. Serology refers to the science of quantifying the number of circulating B lymphocytes in the peripheral blood of a patient? a. True b. False 7. Why would you run paired serum samples (acute and convalescent), instead of a single sample, when conducting quantitative assays for antibody specific for West Nile virus?? a. To determine B cell dysfunction b. To determine if the patient has a T cell defect c. To determine if the patient has an active infection with the virus d. To determine if the patient has a defect in a leukocyte adhesion protein e. All of the above 8. Which of the following assays is the most sensitive for detecting antigen-specific antibody? a. Agar gel immunodiffusion (AGID) b. Enzyme-linked immunosorbent assay (ELISA) c. Agglutination d. They all demonstrate equal sensitivity 9. Which of the following assays is the most qualitative for detecting antigen-specific antibody? 1
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2nd+MIDTERM+KEY+2007 - VM PMI 126 1. 2ND MIDTERM...

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