NSAID.pdf - Classification and Mechanism of Action NSAID...

NSAID
Non steroidal anti-inflammatory Drugs
Preferential
COX
2
Inhibitor
Nimesulide, Diclofenac,
Aceclofenac, Meloxicam, Etodolac
Selective
COX
2
Inhibitor
Celecoxib, Etoricoxib, Parecoxib
Analgesic-Antipyretic
with poor
Anti-inflammatory
Action
Non-Selective
COX Inhibitor
COX-2 gene transcription
mRNA
mRNA
Induced by-
Oxidative Stress, Injury, Ischemia, Seizures
COX- 1 COX- 2
Glucocorticoids
Non-Selective
COX Inhibitor
Non-Selective
COX Inhibitor
Selective
COX
-
2Inhibitor
Celecoxib, Etoricoxib, Parecoxib
Key Point (Solution) - As name Indicate NSAIDs are those agents which are used to get relief from pain, inflammation and fever.
And as per the COX pathway we understand that COX-1 and COX-2 ultimately form prostaglandin which initiates perception of
pain and inflammation . So anyhow if we block or inhibit the synthesis of PG we may reduce pain and inflammation . Although
COX-1 is constitutive in nature thus it always get secreted without induction of injury and called as a house keeper so it’s better to