Chapter 11 - Chapter 11 Tonsels and Adenoids form a ring of...

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Chapter 11 Tonsels and Adenoids form a ring of lymphoid Tissue, Waldeyer’s ring, around entrance of gut and airway Peyer’s patches covered by epithelial layer containing M cells, which have ruffles M cells - Take up pathogen by endocytosis and phagocytosis antigen transported across M cells in vesicles and released at basal surface antigen is bound by dendritic cells, which activate T cells Dendritic cells can extend processes across epithelial layer to capture antigen from gut Two different compartments –epithelium and lamina propria - T cells enter peyer’s patches from blood vessels, directed by homing receptors CCR7 and L-selectin T cells encounter antigen transported across M cells and become activated by dendritic cells activated T cells drain via mesenteric lymph nodes to thoracic duct and return to duct activated T cells expressing alpha4:B7 integrin and CCR9 home to lamina propria and epithelium of small intestine - Gut homing effector T cells bind MAdCAM-1 on endothelium
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Chapter 11 - Chapter 11 Tonsels and Adenoids form a ring of...

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