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Chapter 5 - Chapter 5 Two major intracellular compartments...

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Chapter 5 Two major intracellular compartments, separated by membranes - Cytosol – communicates w/ nucleus vie nuclear pores in nuclear membrane o Cytosol pathogen – degraded in cytosol, binds to MHC I, presented to CD8 Tcells, cell death - Vesicular system – ER, Golgi, endosomes, lysosomes. Continuous with the extracellular fluid o Intravesicular pathogen – degraded in vesicle, present on MHC II to CD4, secretes cytokines to activate macrophage - Cross presentation Pathogens and their products can be found in either cytosolic or vesicular compartment - Extracellular pathogens and toxins o Degraded in endocytic vesicles, binds to MHC II, presented to CD4, activation of B cells to secrete Ig to eliminate toxins MHC I pathway - Cytosolic proteins - Transporter associated with antigen processing - What would the lymphocyte population look like in a TAP knockout mouse o Normal population : B, T, NK cells TAP1 and TAP2 form a peptide transporter in the ER membrane - All transporters of the ATP-binding cassette family composed of 4 domains: 2 hydrophobic transmembrane domains that have multiple transmembrane regions, and two ATP-binding domains - TAP1 and TAP2 encode a polypeptide chain w/ one hydrophobic chain and one
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Chapter 5 - Chapter 5 Two major intracellular compartments...

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