Chapter 10 - Chapter 10 Typical acute infection...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 10 Typical acute infection – Establishment of infection induction of adaptive response adaptive response (antigen starts to go down) immunological memory TH1 subsets - In absence of infection, dendritic cells make TGFB & IL-6 CD4 T cells are activated to express FoxP3 and show regulatory phenotype - In infection, high levels of IL-6 produced Naïve CD4 T cells express RORyT and become TH17 T cells - Viruses and some bacteria induce IL-12 secretion, activates NK cells to produce IFN-y CD4 cells activate from IL-12, differentiate into TH1 - Other pathogens (worms) induce IL-4 secretion, differentiation into TH2 - Activated TH2 cells secrete TGFB & IL-10 inhibit activation/growth of TH2 - Activated TH1 secretes IFN-y inhibits activation/growth of TH2 - Early o TGFB – produced by dendritic cells o IL-6 – dendritic cells produce in presence of infection o TH-17/IL-17 – recruits neutrophils. Up GM-CSF (increase neutrophils and macrophages in bone marrow). -
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 3

Chapter 10 - Chapter 10 Typical acute infection...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online