Chapter 9 - Chapter 9 B cell activation requires Antigen...

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Chapter 9 B cell activation requires Antigen and helper T cells - Neutralization – antibody prevents bacterial adherance - Opsonization – promotes phagocytosis - Complement Activation – activates complement, which enhances opsonization and lysis Two pathways of B cell activation - TD antigen – second signal delivered by helper T cell (CD40) - TI antigen – microbial – second signal can be from antigen itself TH2 cells stimulate B cell proliferation and differentiation - Antigen recognition induces expression of effector molecules by the T cell, which activate B cell B cell proliferation diff into memory cells and plasma cells Linked Recognition B cells and Th2 cells must recognize epitopes of the same antigen in order to interact. Th2 cells have already been activated by Mf and DC presenting the same peptides as B cells. B cell proliferation and antibody production B cell binds to virus through protein coat internalized and degraded peptides presented to T cell, activates B cell B cell produces antibody Vaccine design by linked recognition – B cell binds bacterial polysaccharide epitope
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Chapter 9 - Chapter 9 B cell activation requires Antigen...

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