EPIGENETICS_Doug Brutlag - Disclaimer This is an advanced...

Info icon This preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Doug Brutlag 2011 Disclaimer This is an advanced presentation on epigenetics. Refer mainly to the images to get a flavor of epigenetics. Further reading: http://www.nature.com/scitable/spotlight/epigenetics-26097411
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Doug Brutlag 2011 Genomics, Bioinformatics & Medicine http://biochem158.stanford.edu/ Doug Brutlag Professor Emeritus of Biochemistry & Medicine Stanford University School of Medicine Epigenetics http://biochem158.stanford.edu/Epigenetics.html
Image of page 2
Doug Brutlag 2011 Are epigenetic variations the basis for the differences in Queen bee Vs worker bees ? http://www.nature.com/scitable/spotlight/epigenetics-26097411
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Doug Brutlag 2011 Although identical in genetic sequence, queen bees and worker bees are entirely different in terms of their behavior, physiology, and appearance; Queen bees can produce as many as 2,000 eggs in a single day, whereas worker bees are sterile. Worker bees spend their days foraging for food, collecting pollen, maintaining the hive, and fighting off invaders, while queen bees spend their days having food delivered to them and laying eggs to keep the hive populated with enough workers. Queen bees are 5 times larger than worker bees. Not surprisingly, the life span of queen bees is typically 20 times longer than that of worker bees. Can environmental factors cause epigenetic modifications to DNA? http://www.nature.com/scitable/spotlight/epigenetics-26097411
Image of page 4
Doug Brutlag 2011 What is Epigenetics? C.H. Waddington coined the term epigenetics to mean above or in addition to genetics to explain differentiation. How do different adult stem cells know their fate? o Myoblasts can only form muscle cells o Keratinocytes only form skin cells o Hematopoetic cells only become blood cells o But all have identical DNA sequences.
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Doug Brutlag 2011 C.H. Waddington
Image of page 6
Doug Brutlag 2011 What is Epigenetics? C.H. Waddington coined the term epigenetics to mean above or in addition to genetics to explain differentiation. How do different adult stem cells know their fate? o Myoblasts can only form muscle cells o Keratinocytes only form skin cells o Hematopoetic cells only become blood cells o But all have identical DNA sequences. Modern definition is non-sequence dependent inheritance. How can identical twins have different natural hair colors?
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Doug Brutlag 2011 What is Epigenetics? C.H. Waddington coined the term epigenetics to mean above or in addition to genetics to explain differentiation.
Image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern