L2_NPB_101

L2_NPB_101 - Lecture2 OnlineHandouts Lec2Notes(tonight...

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Unformatted text preview: Lecture2 OnlineHandouts: Lec2Notes(tonight) Announcements: None TheCell PlasmaMembrane MembranePotenBal Reading(Recommended): Chapter3 PrinciplesoftheCellTheory CellissmalleststructuralandfuncBonalunit capableofcarryingoutlifeprocesses FuncBonalacBviBesofeachcelldependon specificstructuralproperBesofthecell Cellsarelivingbuildingblocksofallplantand animalorganisms OrganismsstructureandfuncBonulBmately dependonindividualandcollecBvestructural characterisBcsandfuncBonalcapabiliBesofits cells Cell Fig.21,pg.24 Nucleus Typicallylargestsingleorganizedcell component Enclosedbyadoublelayerednuclear envelope Containscell'sgeneBcmaterial,DNA DNAfuncBons Directsproteinsynthesis ServesasgeneBcblueprintduringcellreplicaBon Cytoplasm PorBonofcellinteriornotoccupiedbythe nucleus Consistsof Organelles "liTleorgans" DisBnct,highlyorganized,membraneenclosed structures Cytosol(~55%ofinternalcellvolume) Complex,gellikemassinwhichthecytoskeletonis found ExamplesofOrganelles EndoplasmicreBculum Proteinandlipidmanufacture Golgicomplex Processesrawmaterialsintofinishedproducts Sortsanddirectsfinishedproductstotheirfinal desBnaBons ServeasintracellulardigesBvesystem Lysosome Mitochondrion MajorsiteofATP(Energysource)producBon PlasmaMembrane PlasmaMembrane Alsocalledthecellmembrane Surroundseverycell Separatescellcontentsfromitssurroundings Separatestwoenvironments:ICFandECF ICF=IntracellularFluid ECF=ExtracellularFluid Controlsmovementofmoleculesintoandout ofcell PlasmaMembrane Extremelythinlayeroflipidsandproteinthat formsouterboundaryofeverycell Controlsmovementofmoleculesbetweenthe cellanditsenvironment ParBcipatesinjoiningcellstoformBssuesand organs Playsimportantroleintheabilityofacellto respondtochangesinthecell'senvironment PlasmaMembraneStructure FuncBonsoflipidbilayer Formsbasicstructureofthemembrane Hydrophobicinteriorservesasbarriertopassage ofwatersolublesubstancesbetweenICFandECF Responsibleforfluidityofthemembrane LipidBilayerofthePlasmaMembrane ECF (water) Polar heads (hydrophilic) Nonpolar tails (hydrophobic) Lipid bilayer Polar heads (hydrophilic) ICF (water) Fig.32b,pg.54 PlasmaMembraneStructure Fluidlipidbilayerembeddedwithproteins Mostabundantlipidsarephospholipids Polarendofphospholipidishydrophilic Nonpolarendofphospholipidishydrophobic Alsohassmallamountofcarbohydrates Onoutersurfaceonly Cholesterol Tuckedbetweenphospholipidmolecules Contributestofluidityandstabilityofcellmembrane PlasmaMembraneStructure Proteins ATachedtoorinsertedwithinlipidbilayer FuncBonsformembraneproteins Spanmembranetoformwaterfilledpathways,orchannels acrosslipidbilayer Serveascarriermolecules Serveasdockingmarkeracceptors Membraneboundenzymes Receptorsites Celladhesionmolecules(CAMs) Proteinsonsurfaceareimportantincells'abilityto recognize"self"andincelltocellinteracBon PlasmaMembraneStructure Membranecarbohydrates ServeasselfidenBtymarkerswhichenablecells toidenBfyandinteractwithoneanother Differentcelltypeshavedifferentmarkers Carbohydratecontainingsurfacemarkersarealso involvedinBssuegrowth PlasmaMembraneStructure ECF ICF Fig.3.3,pg.55 MembraneTransport CellmembraneisselecBvelypermeable TwoproperBesofparBclesinfluencewhether theycanpermeatecellmembranewithout assistance RelaBvesolubilityofparBcleinlipid SizeoftheparBcle TypicalIonChannel TheNa+/K+ATPaseisaCarrierProtein Modelofthesodiumpotassiumpump. PlasmaMembrane Fig.32c,pg54 MembranePotenBals TermstoKnow PotenBal=V(orE) Current=I Resistance=R RelaBonship:V=IR ForcesThatActonPermeantParBcles: Chemical ConcentraBonDifferences Fig.3.8,pg.62 ForcesThatActonPermeantParBcles: Electrical ChargeDifferences UnequalDistribuBonofIons Fig.320,pg.75 ...
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This note was uploaded on 04/17/2008 for the course NPB 101 taught by Professor Fuller,charles/goldberg,jack during the Spring '08 term at UC Davis.

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