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L5_NPB_101 - Lecture5 OnlineHandouts Lec4&5Notes Review...

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Lecture 5 Online Handouts: Lec 4 & 5 Notes Announcements: None Reading ( Required ): Reading: Ch 4 (pp 104‐108) Neurotransmi1ers & Neuromodulators Reading (Recommended): Reading: Ch 4 (pp 101‐111) Review AcEon PotenEal AcEon PotenEal (cont’d) ConducEon of AP Synapse
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REV: AcEon PotenEal 1. Rapid stereotyped change in E m , which occurs in response to a sEmulus. 2. There are 6 primary characterisEcs of an AP: a) Large regeneraEve increase in P Na via PosiEve Feedback b) Rapid repolarizaEon of E m by slow increase in P K c) Every AP followed by 2 refractory periods d) Every AP is All‐or‐None e) AP conducted over the axon f) AP are conducted rapidly
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At Any Point of the AcEon PotenEal, The E m is a FuncEon of P Na+ AND P K+ Absolute refractory period Relative refractory period Action potential Na+ permeability K+ permeability Fig. 4‐13, pg. 97
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Voltage‐Gated Channel ProperEes Affect the Neuronal Firing Rate Refractory Periods A new acEon potenEal usually cannot be iniEated in a region that just had an acEon potenEal Why? InacEvaEon of the populaEon of voltage‐gated Na + channels Absolute refractory period Relative refractory period Action potential Na+ permeability K+ permeability Fig. 4‐13, pg. 97
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Voltage‐Gated Channel ProperEes Affect the Neuronal Firing Rate Absolute Refractory Period A new acEon potenEal ABSOLUTELY cannot be iniEated no mafer how much sEmulaEon is given Why? Not enough voltage‐gated Na + channels have recovered from inacEvaEon Absolute refractory period Relative refractory period Action potential Na+ permeability K+ permeability Fig. 4‐13, pg. 97
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Voltage‐Gated Channel ProperEes Affect the Neuronal Firing Rate RelaEve Refractory Period A new acEon potenEal MIGHT BE iniEated The sEmulus must be stronger than normal Absolute refractory period Relative refractory period Action potential Na+ permeability K+ permeability Fig. 4‐13, pg. 97
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Voltage‐Gated Channel ProperEes Affect the Neuronal Firing Rate RelaEve Refractory Period WHY? More voltage‐gated Na + channels have recovered from inacEvaEon. BUT, a hyperpolarizing current sEll flows through the voltage‐gated K + channels.
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