{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

NPB 114 final condensed notes

NPB 114 final condensed notes - NPB 114 final condensed...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
NPB 114 final condensed notes Pancreas: tadpole shape Produces exocrine secretions (end up in duodenum) that neutralize chyme coming from the stomach into the duodenum Produces digestive enzymes (in acinar cells) o proteases to break apart protein o amylases to break apart carbohydrate o lipase to break apart fat/triglyceride Located caudal to the stomach with one or two ducts leading from the pancreas to the duodenum of tract o major ampulla duct is always present, minor ampulla is small and may be nonfunctional major ampulla also has billiary duct to gall bladder lipase requires biliary secretions to work properly o secretions are made and altered in the acinus of the pancreas (like salivary gland-salivon) Acinar cells: aww, flower petals that produces allll the enzymes Produces the enzymatic components of EXOCRINE secretions necessary for digestion o No endocrine secretions: hormones Neutral to basic optimal pH 7.4- 8 Store and released as precursor enzyme 1. Pancreatic Proteases: Proteolytic protein digestion within duodenum Proteases stored and secreted as precursor to enzymes Activated in duodenum Storage as precursor to protect the pancreas o Disease state when enzymes are inappropriately activated in the pancreas. Soo inappropriate, don’t you know you’ll get pancreatitis?? o Dude! Trypsin will digest the pancreas WHOA, that’s horrible! o It’s ok! There’s a trypsin inhibitor in the pancreas to crush any accidental activation of trypsin in the pancreas…die trypsin! Inactivation of enzymes also carried out by trypsin in the duodenum o Ok Trypsin, showoff! Trypsin can activate and inactivate precursor enzymes and break down protein in chyme a. Trypsinogen TRYPSIN** active in duodenum - activated by enterokinase (enterokinase secreted by epithelial cells on apical side of small intestine, only purpose is to activate trypsinogen into trypsin) - activated by autocatalization , activated by presence of trypsin why have someone do it when you can do it yourself??! b. Chymotrypsinogen CHYMOTRYPSIN** - Catalyzed by trypsin
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
trypsin can do it for everyone! c. Procarboxypeptidase A,B CARBOXYPEPTIDASE A**, B** - Catalyzed by trypsin go Trypsin, go Trypsin, you can do it, you rock it!! 2. Pancreatic Amylase: carbohydrate digestion Alos works best at neutral pH Strongly inhibited by acid Stored and secreted in the active form..who cares? We’re not made out of carbohydrate hahaha you can’t hurt me Target α-1,4 glycosidic bond found in starches o Downward bond btw glucose molecules Amylase cannot target terminal glucose in starches…kiss my butt o You will end up with a non-absorbable dissacharide Alpha amylase cannot target α-1,6 glycosidic bond (esterified sidearm) 3. Pancreatic Esterases/Lipases: fat digestion, break down esterified bond in fats, phospholipid, and cholesterol ester target fats or fat soluble molecule at the optimal neutral pH 1. Pancreatic lipases: -produce, store, secrete in active form
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}