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Lecture 20a - ANNOUNCEMENTS LECTURE 20 1 HOMEWORK...

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LECTURE 20 ANNOUNCEMENTS 1. HOMEWORK ASSIGNMENTS AS IN LG FOR THIS WEEK, PLUS pp 342-363 & Ch.10 #4&7. 2. RASMOL #6, CHYMOTRYPSIN (WILL APPEAR ON MIDTERM EXAM) 3. REMINDER: NO QUIZ NEXT WED 10/18 4. e-MAIL PROF IF YOU WANT TO TAKE THE MAKE-UP EXAM AND YOU ARE ELIGIBLE. YOU ARE ELIGIBLE IF YOU HAVE A DIRECT CONFLICT, 3 EXAMS/24HRS, OR YOU ARE SICK. e-MAIL PROF ABOUT A CONFLICT BEFORE NOON ON FRIDAY 10/13. LECTURE OF FRIDAY 10/6 1. CHYMOTRYPSIN SUMMARY HIS ACTS TWICE AS AN ACID, TWICE AS A BASE SER 195 , THEN WATER, MAKE NUCLEOPHILIC ATTACKS CAN PLACE EVERY STEP ON A G o VS PROGRESS OF RXN DIAGRAM EVEN MUTATION OF ACTIVE SITE SER OR HIS (TO ALA) DOES NOT ELIMINATE ALL CATALYSIS! THE ENZYME STILL BINDS THE TS AND LOWERS ITS G o 2. MANY PROTEINS HAVE COENZYMES AND/OR METAL IONS REGULATION OF ENZYME ACTION 3. CONTROL OF PROTEIN SYNTHESIS & DEGRADATION 5. MEET FRI 10/13 1:25PM COMSTOCK B106. “HOW TO STUDY FOR THIS COURSE”. NO DISCUSSION OF MATERIAL ON MIDTERM EXAM (THAT DISCUSSION MONDAY, IN CLASS); DISCUSSION WILL BE POSTED AS AN ADDENDUM TO FRIDAY LECTURE . TODAY HOW TO CONTROL AN ENZYME'S ACTIVITY? e-MAIL PROF ABOUT A CONFLICT BEFORE NOON
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ACTIVE R INACTIVE T ENZYME REGULATION II. CONTROL OF ENZYME ACTIVITY B. ALLOSTERIC CONTROL IN GENERAL, REGULATED ENZ HAVE 2 STATES: (1) ACTIVE ; (2) LESS ACTIVE.
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