Exam 2 Key mod

Exam 2 Key mod - Name _ Student ID # _ BICD 140 Spring 2006...

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Name ______________________ - 1 - Student ID # ___________ BICD 140 Spring 2006 Midterm Exam #2 Please write your name on each page and look through your exam. It should have 9 pages. Do not use pencil or white out on your exam. Be certain that all of the work that you want graded is written in permanent ink. Your score Question 1-15. 15 points possible ________ Question 16-25. 10 points possible ________ Question 26. 12 points possible ________ Question 27 18 points possible ________ Question 28 24 points possible ________ Question 29 15 points possible ________ Question 30 25 points possible ________ (Bonus 5 points possible ________) Total possible 119 points possible ________ Graded exams will be distributed after class as soon as they are graded. If you will not pick up your exam then, you may sign below to signify that you have given your permission for your exam to be distributed in a way that may subject it to public scrutiny. Signature_____________________
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Name ______________________ - 2 - Answer the following True (a)/False (b) questions on your scantron, 15 points, 1 point each. 1. Rag proteins are expressed only once during T/B cell development. F 2. CD4 + and CD8 + bind to variable regions of MHC molecules. F 3. A brother and sister will likely have the same MHC haplotype. F 4. CD1 is an MHC-like molecule which presents lipids and lipopeptides to NKT cells. T 5. Upregulation of MICA, an MHC-like molecule, targets a cell for NK killing by recognition of NKG2D. T 6. Superantigens mediate peptide-specific activation of T cells. F 7. Transcription of the Ig locus begins only after rearrangement. F 8. The T cell receptor signals through the TCR alpha cytoplasmic domain. F 9. A double positive thymocyte may differentiate to an alpha/beta T cell or a gamma/delta T cell. T 10. T cell precursors are present only in the thymus. F 11. Both new T and B cells are generated in similar numbers each day. F 12. Recognition of antigen by an immature B cell will always leads to receptor editing. F 13. Encapsulated bacteria (the pyogenic or pus forming ones) are particularly susceptible to lysis by complement deposition by the Alternate pathway. F 14. Most developing thymocytes die as a consequence of negative selection. F 15. One downside of rearrangement is the chromosomal translocations of oncogenes into the Ig locus, leading to leukemias. T
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Name ______________________ - 3 - Answer the following multiple choice questions on your scantron, 20 points, 2 points each: 16. During development B cells receive signals from stromal cells, these include: a) IL-7/IL-7R b) SCF/cKit c) IL-4 d) a and b. e) All of the above 17. Mutations in which of the following genes would likely result in agammaglobulimia, the inability to make antibodies: a) Bruton’s tyrosine kinase b) Ig ! c) VpreB
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Exam 2 Key mod - Name _ Student ID # _ BICD 140 Spring 2006...

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