exam1key - Name _ Question 1: For each of the following,...

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Name __________________ 1 Question 1: For each of the following, identify the one cell type that best fits the description? (14 pts) i. Can phagocytose bacteria, but does not present antigens from those bacteria to T cells. NEUTROPHIL ii. Capable of rapidly clearing virally-infected cells by cytotoxic mechanisms, but is not a T cell. NK CELL iii. Can phagocytose bacteria and produce cytokines that are important to the early innate response. MACROPHAGE iv. Can produce large amounts of secreted antibody, but does not express surface immunoglobulin. PLASMA CELL OR PLASMACYTE v. Can bind IgE with high affinity, causing histamine release and expulsion of parasites. MAST CELL OR EOSINOPHIL (BASOPHIL ALSO ACCEPTABLE?) vi. Lyse cells infected with viruses or intracellular pathogens by recognizing fragments of those pathogens presented on the infected cell surface. CD8+ T CELL OR CTL OR CYTOTOXIC T CELL vii. Provides the essential link between the innate and adaptive immune responses. DENDRITIC CELL Question 2: Choose the answer combination that best fills in the blanks for each statement (21 pts) i. An example of adaptive immunity amplifying innate immunity is the production of ____ by ______ which amplifies the _____ activity of _____. a) IFN- ! , B cells, cytotoxic, NK b) antibodies, B cells, phagocytic, macrophage c) IFN- ! , T cells, cytotoxic, NK d) antibodies, B cells, bacteriocidal, J cells e) b and c E
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Name __________________ 2 ii. An example of an “alarm” cytokine produced during inflammation is _____ which leads to _______ by the ______. a) IL-1, fever induction, hypothalamus b) IL-6, acute phase response, liver c) TNF- " , increased metabolism, fat/muscle d) TNF- " , stimulates migration, dendritic cell e) All of the above E iii. Cells that become virally-infected can communicate this via the production of ______ which can have effects on neighboring cells such as _____ and ______. a) IFN- " and – # , release of histamines, RAG activity in B cells b) IL-6, increase MHC class I expression, activation of NK cells c) IFN- " and – # , resistance to viral replication, increased MHC class I expression d) histamines, TdT activity, activation of CD8 + T cells e) IFN- ! , increased phagocytosis, opsonization C iv. During the B cell response to antigen the composition of the antibody being generated changes in the following ways: a) increased affinity, more IgM, mutations in the hypervariable region b) increased affinity, more IgG, mutations in the hypervariable region c) lower affinity, more IgM, mutations in the hypervariable region
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This note was uploaded on 04/17/2008 for the course BICD 140 taught by Professor Goldrath during the Fall '07 term at UCSD.

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exam1key - Name _ Question 1: For each of the following,...

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