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Final exam review questions

Final exam review questions - These are some final exam...

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These are some final exam questions from Spring 2006. The Fall 2006 Final will not be all multiple choice. 1. Components of G-protein signaling pathways might include all of the following except: A. Second messenger B. Protein that binds and hydrolyzes ATP C. Ion channel D. Enzyme E. Hydrophobic signaling molecule F. All of the above are found in G protein pathways 2. A Gs protein, when active: A. has GDP bound to the α subunit E. has GTP bound to the α subunit B. has GTP bound to the β subunit F. has GDP bound to the β subunit C. has ATP bound to the α subunit G. has ADP bound to the β subunit D. has ATP bound to the β subunit H. has ADP bound to the α subunit 3. Nitric oxide (NO) 4. Put the following events in the correct order: 1. G protein linked receptor is activated 2. Phospholipase C is activated 3. Calcium activates protein kinase C 4. PIP2 is cleaved 5. Gq α subunit dissociates from the βγ complex 5. All of the following require Ca++ EXCEPT: 6. If you became infected with cholera, all of the following might happen EXCEPT: A. profuse watery diarrhea B. increased cAMP levels C. Chemical modification of the Gs α subunit of a monomeric G protein D. Increased adenylyl cyclase activity E. All of the above would happen 7. G protein receptor Kinase: 1
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8. Which of the following proteins would be not function properly if the associated GEF was mutant/non-functional? 9. The growth factor Superchick stimulates proliferation of cultured chicken cells. The receptor that binds Superchick is a receptor tyrosine kinase, and many tumor cell lines have mutations in the gene that encodes this receptor. Which of the following types of mutations would be expected to induce uncontrolled cell proliferation?
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