BICD 110Spring2006Final

BICD 110Spring2006Final - BICD 110 Spring 2006 Final...

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BICD 110: Spring 2006 Final Multiple Choice Questions 1. Components of G-protein signaling pathways might include all of the following except: A. Second messenger B. Protein that binds and hydrolyzes GTP C. Ion channel D. Enzyme E. Hydrophobic signaling molecule F. All of the above are found in G-protein pathways 2. A Gs protein, when active: 3. Nitric Oxide (NO) 4. Put the following events in the correct order: 1. G- protein linked receptor is activated 2. Phospholipase C is activated 3. Calcium activates protein kinase C 4. PIP2 is cleaved 5. Gqα subunit dissociates from the βγ complex 5. All of the following require Ca++ EXCEPT: A. cadherin binding to cells B. activation of protein kinase C C. calmodulin activity D. exocytosis of acetylcholine E. all of the above require Ca++
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6. If you become infected with cholera, all of the following might happen EXCEPT: 7. G protein receptor Kinase: 8. Which of the following proteins would function properly if the associated GEF was mutant/non- functional? 9. The growth factor Superchick stimulates proliferation of cultured chicken cells. The receptor that binds Superchick is a receptor tyrosine kinase, and many tumor cell lines have mutations in the gene that encodes this receptor. Which of the following types of mutations would be expected to induce uncontrolled cell proliferation? A. A mutation that prevents localization of the receptor to the plasma membrane. B. A mutation that prevents dimerization of the receptor C. A mutation that destroys the kinase activity of the receptor D. A mutation that prevents recognition of the receptor by phosphatases E. A mutation that prevents ligand binding
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