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Lecture 6 - Risk Assessment and Standards Lecture#6 Risk...

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1 Risk Assessment and Standards Lecture#6 Risk Assessment and Standards Cancer Risk and Setting Standards (ICP#2b) Non Carcinogens and Setting Standards (ICP#3) Reading: R: Ch 14 (sections 14.1 – 14.6) Overview What is an acceptable risk for setting air and water quality standards? What procedure is used to set water quality standards for carcinogens; non-carcinogens (ICP#3)? What procedure is used to set air quality standards? How does one estimate Rfd or RfC values for setting standards? Risk Assessment (steps) Hazard Assessment: What are the adverse health affects of the chemicals in question? Dose-Response: How much of a chemical causes a particular adverse effect? Exposure assessment: How much of a chemical reaches the boundary of a person and how much enters the persons body? Risk characterization: How great is the potential for adverse impact from this chemical (e.g., incremental cancer risk)? Dose-Response: Chronic Toxicity Carcinogenic vs non-carcinogenic; threshold vs non threshold- different approaches to estimate risk Risk Assessment and Standards Risk assessment and standards for carcinogens (no threshold) set standard at zero Risk assessment carcinogens or non-carcinogens (threshold) based on PF and 1/10 6 risk for cancer based on RfD (reference dose) Setting air quality standards similar to water quality standards but using air exposure data (PF, RfC) Hazard Assessment for Carcinogen Potency Factor: from the slope of the dose-response curve y = mx (when x=1, then y = m, the potency factor); the greater the value, the more toxic a chemical the greater PF, the greater the risk
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