Lecture 8a - ANNOUNCEMENTS LECTURE 8 1 DO LG PROBLEMS 10 17...

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LECTURE 8 ANNOUNCEMENTS 1. DO LG PROBLEMS 10 - 17 FOR THIS WEEK. RASMOL ASSIGNMENT #3, STRUCTURAL DOMAINS. 2. MAKE-UP EXAM FOR MIDTERM: PROBABLE DATE FRI 10/20 OR SAT. PROF WILL MEET IN A FEW WEEKS WITH STUDENTS WHO HAVE A CONFLICT TO CHOOSE A TIME. 3. FOR ALL THE SCRIPTED RASMOL ASSIGNMENTS (i.e. EXCEPT FOR THE TOUR OF THE PROTEIN DATA BANK): OPEN RASMOL. IN COMMAND LINE, TYPE "SCRIPT INDEX.SPT" 4. ANY STUDENT WHO HAS JUST ADDED THIS CLASS: MEET PROF RIGHT AFTER LECTURE TO DISCUSS HOW TO CATCH UP. FRIDAY’S LECTURE: COLLAGEN STRUCTURE STRUCTURAL DOMAINS, SUPERFAMILIES, FAMILIES MULTIDOMAIN PROTEINS TODAY'S LECTURE: QUATERNARY STRUCTURE (IV) PROTEIN STABILITY
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REPEATED DOMAINS OCCUR (WITHIN SINGLE POLYPEPTIDE CHAIN) COMPLEMENT CONTROL PROTEIN DOMAIN (C) IMMUNOGLOBULIN DOMAIN (I) FIBRONECTIN TYPE I DOMAIN (F1) GROWTH FACTOR DOMAIN (G) MANY PROTEINS: POLYPEPTIDE CHAIN HAS REPEATING RUNS OF SAME STRUCTURAL DOMAIN KRINGLE DOMAIN (K)
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AQUEOUS PROTEINS OR PROTEINS IN THE MEMBRANE BIOMEMBRANE FIBRONECTIN BLOOD CLOTTING FACTOR XII BLOOD CLOTTING FACTORS VII, IX, & X COMPLEMENT PROTEIN 2 N-CAM, A CELL ADHESION PROTEIN INTERLEUKIN-2 RECEPTOR PROTEIN PLATELET-DERIVED GROWTH FACTOR RECEPTOR EXAMPLES OF “MULTIDOMAIN” PROTEINS (SCHEMATIC PICS) FIBRONECTIN INTERACTS WITH CELL SURFACE AND EXTRACELLULAR MATRIX THESE PROTEINS ARE SINGLE CHAINS WITH MANY REPEATED, AND MANY DIFFERENT, FOLDING UNITS FIBRONECTIN DOMAINS GROWTH FACTOR DOMAIN KRINGLE DOMAIN COMPLEMENT CONTROL PROTEIN DOMAIN IMMUNOLGLOBULIN DOMAIN OTHER PARTS OF THE PROTEIN
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IMMUNOGLOBULIN G JARGON: A “SUBUNIT” = ONE POLYPEPTIDE CHAIN IN GENERAL , WHAT HOLDS CHAINS TOGETHER?
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