Quiz 4 - Your e-mail_KEY A QUIZ 4a 1(12 pts Draw O 2...

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Your e-mail____KEY A _____ QUIZ 4a 9/28/05 1. (12 pts) Draw O 2 binding graphs, label the axes , write two numerical values including units, if any, on each axis , and label as A, B, C, D, E showing: A. adult Hb, without BPG B. adult Hb + BPG C. Hb that has been dissociated into individual, separated α and β chains. D. Mb E. fetal Hb (+ BPG) 2. (4 pts) Name two negative allosteric effectors of Hb: _ BPG ____ and __ H+ ____ CO2 ALSO OK Name two positive allosteric effectors of Hb: __ O2 ___ and ___ CO ____ 3. (4 pts) Circle T if true, F if false: T F The III structure of Hb α chain, Hb β chain, and Mb look very much the same. T F The I structure of Hb α chain, Hb β chain, and Mb look very much the same. T F Nowadays, researchers can calculate the correct structural domain given the AA sequence from "basic principles". T F Mb has higher affinity for oxygen than does Hb at essentially all physiological pO 2 . 4. (4 pts) The equilibrium constant K eq for the binding of O 2 to Mb is 2 x 10 6 M -1 , where K eq = [Mb O 2 ]/[Mb][O 2 ] . The rate constant for combination of O 2 with Mb is 1 x 10 7 M -1 sec -1 . What is the rate constant for dissociation of O 2 fromMb? K eq = k assoc /k dissoc = 2 x 10 6 M -1 = (1 x 10 7 M -1 sec -1 )/k dissoc k dissoc = (1 x 10 7 M -1 sec -1 )/( (2 x 10 6 M -1 ) = 5 sec -1 5. (6 pts) Refer to the color projected image and the image on the right.
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  • Summer '07
  • FEIGENSON,GW
  • MB

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