ap0420 - APII Urinary Sys P.II 04/20 Kidney Physiology...

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APII Urinary Sys P.II: 04/20 Kidney Physiology: Urine Filtration 1. Glomerulus filtration 2. Tubular reabsorption (capillaries or vasa recta) 3. Tubular secretion (items moved into filtrate to be urinated out) * 2 & 3 are opp Whatever comes out of the collecting duct becomes urine 180L/day filtered per day ; urine is filtered blood ; vast majority of the filtrate is reclaimed by the body Glom. Filtration decided by pressure ; the glo. Is a capillary passive hydrostatic pressure HPGC press in glo capillary ( same thing as glo BP; the amount of blood flushing into the glo cap. ; this is high pressure; pushes out HPCS pressure in the capillary space; the pressure the filtrate in the cap space is exerting back into the glo ; the force opposite direction of hpgc ; pushes solutes in OPGC osmotic pressure inside the glo; the pressure exerted from the solutes; pushes solutes in o When water exits the glo; solutes remain and pull water back in Net filtration Pressure: (NFP) about +10mmHg ; materials are filtered out more than in bc its positive; it will determine the GFR Glomerulus filtration rate (GFR) the amount of filtrate produces by the glo in both kidneys per min (volume wise); about 120-125mL/min o Influences by NFP; the higher the pressure the higher the GFR (you will increase the amount of filtration) o Total SA of the glo it’s a capillary so if you increase SA of the glo you increase the amount that can be filtered; o Filtration membrane permeability glo capillary (endothelium; very porous ) + bowman’s cap visceral layer (this capsule has a double layer parietal and visceral layer) ; this filtration membrane is very
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