37 - ANNOUNCEMENTS LECTURE 37 1. READING 787-798 &...

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LECTURE 37 ANNOUNCEMENTS 1. READING 787-798 & 804-829; PROBLEMS AS IN LG FOR THIS WEEK. 2. “MAKE-UP QUIZ” WED 11/28. COVERS LECTURES 11/12, 11/14, 11/16, AND TODAY. TURN IN THE MAKE-UP QUIZ ONLY IF FEWER THAN 9 QUIZZES HAVE BEEN PREVIOUSLY TAKEN . YOU MIGHT HAVE MISSED ONE OF THOSE 9 QUIZZES FOR ANY REASON-- THE REASON IS NOT IMPORTANT. 3. MUST LET PROF KNOW ABOUT FINAL EXAM CONFLICT BEFORE NOON ON WED 11/28. 4. NO CLASS ON WED 11/21 FRIDAY’S LECTURE 1. CALVIN CYCLE: 3 STAGES, (i) FIX CO 2 ; (ii) SYN SUGAR; (iii) REGENERATE Ru-1,5-BP TODAY BIOSYN OF FAT AND PHOSPHOLIPID THE CHOLESTEROL STORY 2. FA BIOSYN: (i) ROLE OF MALONYL-CoA; (ii) FA SYNTHASE ENZ: CHANNELLING FA BIOSYN; LOCAL AND HORMONAL CONTROL 5. NO OFFICE HOURS OR REVIEW SESSIONS THIS WEEK GLUCONEOGENESIS MAIN SITE IS THE LIVER MAIN STARTING MOLECULES: LACTATE AND ALA "BYPASS" OF ONLY 3 STEPS OF GLYCOLYSIS MAIN REGULATION: PYRUVATE CARBOXYLASE REQUIRES ACETYL-CoA 6. REVIEWS/OFFICE HRS FOR STUDY WEEK ARE NOW POSTED ON BLACKBOARD. EACH REVIEW COVERS ENTIRE COURSE.
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LONG, FLEXIBLE ARM OF ACYL CARRIER PROTEIN (ACP) 7 DIFFERENT ACTIVE SITE S PRODUCTS STAY BOUND UNTIL LAST STEP: CHANNELING ANIMALS: 1 POLYPEPTIDE WITH 7 ACTIVE SITES BINDING STEPS. NO RXN YET FATTY ACID SYNTHASE 8 ACETYL-CoA + 7 MALONYL-CoA + 14 NADPH + 20 H + PALMITIC ACID + 7 CO2 + 14 NADP + + 7H 2 O + 8 CoA ON THIS PAGE: WEIRD DIAGRAM, SHOWING INTERMEDIATES “IN SPACE”-- REALLY, IN ACTIVE SITES OF ENZYMES!! BACT., PLANTS: 7 DIFF POLYPEP .
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FATTY ACID SYNTHESIS NOTES ELONGATION: e.g. 16:0 18:0 20:0 etc " ENZYME: 9 UNSATURATION: e.g. 16:0 16:1 or 18:0 18:1 9 ENZYME: MAMMALS CANNOT ADD UNSATURATION BETWEEN AND TERMINAL METHYL! 9
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37 - ANNOUNCEMENTS LECTURE 37 1. READING 787-798 &...

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