Prion_2 - Prion Propagation Remember prions propagate by...

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Prion Propagation •Remember, prions propagate by converting other copies of the same protein to an infectious form (the “prion form”). –The infectious form of prions that has been best studied is a condensed amyloid (literally a “starch-like substance”, used to describe a hard waxy deposit of protein and/or polysaccharides that is often correlated with tissue degeneration). Prion Propagation •Conversion to the infectious form can have several different results: –A toxic amyloid - in TSEs (Transmissible Spongiform Encephalopathies) –An inactive (or less active) protein in amyloid form - PSI , PIN , URE3 –An active protein in amyloid form - [ß], Het-s and C (the last two are Podospora anserina prions) •[ß] and C may not be amyloids when infectious. Genetic Criteria for Prions •The simplest criterion is non-Mendelian inheritance in crosses. –If a [ PSI + ] haploid (shown with green dots representing amyloids) is crossed with a [ psi - ] haploid, the resulting diploid is [
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This note was uploaded on 04/17/2008 for the course PCB 3063 taught by Professor Marta during the Spring '08 term at University of Florida.

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Prion_2 - Prion Propagation Remember prions propagate by...

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