Corbit summary - Electrolytic lesions-contingency...

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Erin LaVanway April 1, 2008 Physiological Psych. Corbit Summary Rationale: The rationale of this was to study how rats learn the consequences of their actions and examine the role of the hippocampus in learning. Objective: The objective of this experiment was to determine and examine the role of electrolytic and excitotoxic lesions in the subiculum and entorhinal cortex and their affect in contingency degradation. Method: Subjects: Experiments 1,2, & 3 used male rats Experiments 4 & 5 used female rats Apparatus: 12 operant chambers Lesion: Electrolytic: destroy an area by shooting a current through it. Excitotoxic: neurons pick up NMDA and NMDA destroys that area. Control: do everything the same (lesions), but don’t destroy an area. Behavioral Procedures: Operant training-get them to press the lever Contingency degradation-get the rats to only press the lever if they have to Devaluation-feed them before the experiment to see if they still press the lever Experiment 1:
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Unformatted text preview: Electrolytic lesions-contingency degradation Experiment 2: NMDA lesions-contingency degradation Experiment 3: both lesions-contingency degradation and retrained for devaluation Experiment 4: NMDA lesion of the retrohippocampus Experiment 5: Disconnection procedure-electrolytic lesion to dorsal hippocampus-excitotoxic to entorhinal cortex and subiculum. Results: Experiment 1: prevented learning Experiment 2: no effect Experiment 3: degradation-same as experiments 1 and 2. Devaluation-no effect. Experiment 4: had an effect Experiment 5: Entorhinal cortex-had an effect. Subiculum-no effect. Conclusion: Main input if from Entorhinal cortex and when you lesion this you prevent learning. Electrolytic lesions prevent learning. Critique: They switched subjects during the experiment; using different genders allows for less control in the experiment and there could have been hormonal issues that played into the results because of this....
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