Study Questions 6 1. What parts do each somite become divided into (5 parts)? Major somite components: 1. Sclerotome – vertebrae, ribs and rib cartilage 2. Myotome – musculature of the back, ribs, limbs, abdominal wall 3. Dermatome – forms dermis of the back Minor components: 4. Syndetome – tendons 5. Endothelial Cells - cells that generate vascular cells in the dorsal aorta 2. Draw the relative geometric shapes and positions of the dermatome, sclerotome and two subdivisions of the myotome in respect to the notochord, neural tube, lateral plate mesoderm and overlaying epidermis. Why is this particular arrangement important?
3. Which proteins control somite boundaries? 4. Explain the results of the following experiment involving protein Notch
When quail NON-boundary cells are transplanted into the unsegmented paraxial mesoderm of a chick, ANDlocal ectopic expression of Notchis induced in the graft by electroporation (of the activated Notch protein) ⇒graft induces a somite boundary in the host!OR
5. How does protein Notch influence gene expression? 6. What is the current theory explaining somite formation involving Notch and Hairy 1 (among other factors)?
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- Summer '14
- Intramembranous ossification, Endochondral ossification, Paraxial mesoderm