Study questions 8 - Study Questions 8 Starting from Lecture 15 1 Define proximal-distal anterior-posterior and dorsal-ventral limb axis There are three

Study questions 8 - Study Questions 8 Starting from Lecture...

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Study Questions 8, Starting from Lecture 15 1.Define proximal-distal, anterior-posterior and dorsal-ventral limb axis.There are three axes 2.Is the following statement true or false: Wnt proteins stimulate the degradation of Fgf10 in the lateral plate mesoderm, thereby initiating limb bud formation? Explain your reasoning.
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3.Describe the roles of Fgf10, Fgf8, Wnt2b, Wnt8c and Wnt3a in the initiation of the chicken limb bud formation. How the above molecules interact with each other to signal the formation of the limb budFGF10, secreted by the lateral plate mesoderm is what induces the limb budformation. Limb bud formation is localized by wnt 2b and wnt 8c. wnt 2b is 4.Describe the roles of FGFs, Tbx5 and Tbx4 during limb bud formation in the chick. Outline the experiments which demonstrated the roles of the above proteins.
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  • Summer '14
  • Developmental Biology, Sex-determination system, apical ectodermal ridge, Limb Bud, limb development

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