Chapter 20 - Genomics and Proteomics

Chapter 20 - Genomics and Proteomics - Chapter 20 Genomics...

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Chapter 20 Genomics and Proteomics Genomics encompasses several subfields - genomics field of the study of genomes o structural genomics includes construction of genomic sequence data, gene discovery, and localization and the construction of gene maps o functional genomics studies biological function of genes and their regulation and products o comparative genomics compares gene or protein sequences from different genomes to elucidate functional and evolutionary relationships - proteomics outgrowth of genomics – study of the proteins present in a cell at a given time under a given set of conditions o identification of all proteins expressed in a cell at a given time under a given set of conditions o nature and extent of any posttranslational modification of proteins o nature and extent of protein-protein interactions in the cell o subcellular location of proteins in various cellular compartments - Human Genome Project (HGP) gathering and analyzing genome information is a large-scale, labor-intensive endeavor requiring the coordinated effort of many laboratories Genomics: Sequencing is the Basis for Identifying and Mapping All Genes in a Genome - clone-by-clone method construction of cloned libraries of large fragments that include all DNA in an organisms’s genome
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Chapter 20 - Genomics and Proteomics - Chapter 20 Genomics...

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