Louis Pasteur (1822-1895) – yeast causing fermentation, pasteurisation for milk, proposed GermTheory of Disease, swan-neck flask experiment, relationship between micro-organisms and disease,and produce various vaccines and established principles of immunityRobert Koch (1843-1910) – developed agar plate techniques, studied anthrax, determine disease iscaused by specific microbes, and developed Koch’s PostulatesKoch’s PostulatesPurpose: to identify that a specific micro-organism is responsible for a disease1.The same microbe must be present in every infected host2.The microbe must be taken to be cultured and grown3.The cultured microbe must be taken to infect a healthy organism, who develops the samesymptoms as the first host4.The microbe from the infected host must be taken and cultured, then identified as theoriginal microbePrions – pathogen, microbe, non-cellular, proteinsViruses – pathogen, microbe, non-cellular, protein coatBacteria – pathogen, microbe, cellular, prokaryotic
